Circulating levels of N -(carboxymethyl)lysine are increased in systemic sclerosis
نویسندگان
چکیده
منابع مشابه
Increased Circulating miR-10a Levels Associated with Multiple Sclerosis
Background: Multiple sclerosis (MS) is an autoimmune disease that causes chronic inflammation of the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs 19–24 nucleotides long, which are differentially expressed in different tissues. The role of miRNAs in MS remains unclear. We assessed miR-10a transcript levels in MS patients during recurrence and two months after relapse. Ma...
متن کاملCirculating levels of Ne-(carboxymethyl)lysine are increased in systemic sclerosis
Objective. Advanced glycation endproducts (AGEs), including Ne-(carboxymethyl)lysine-protein adducts (CML) are involved in micro/macrovascular changes and are co-localized with adhesion molecules in inflamed tissues. Serum levels of CML were investigated in systemic sclerosis (SSc) characterized by microvascular modifications and correlated with indices of micro/ macrovascular damage. Methods. ...
متن کاملIncreased circulating levels of tissue kallikrein in systemic sclerosis correlate with microvascular involvement.
BACKGROUND In systemic sclerosis (SSc) the lack of an angiogenic response to hypoxia may be due to inappropriate synthesis of angiogenic and angiostatic factors. Tissue kallikrein (t-kallikrein), regulating the kallikrein-kinin system and acting on the microcirculation, is a potent angiogenic agent, and kallistatin is its natural inhibitor. OBJECTIVE To evaluate, in patients with SSc, t-kalli...
متن کامل[Raised levels of circulating endothelial cells in systemic sclerosis].
OBJECTIVE Circulating endothelial cells (CECs) have been described in different conditions with vascular injury. Vascular abnormalities play a key role in the pathogenesis of Systemic Sclerosis (SSc). The aim of our study was to look for the presence of CECs in SSc patients and to evaluate their clinical significance. METHODS We studied 52 SSc patients and 40 healthy controls (HC). Five-param...
متن کاملIncreased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes
Background: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. Objective: To evaluate AIM2 expression and activation as well as circulating mtDNA levels in T2D patients. Methods: AIM2 expres...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rheumatology
سال: 2007
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kel076